Gelatin-binding Region of Human Matrix Metalloproteinase-2
نویسندگان
چکیده
منابع مشابه
Gelatin-binding region of human matrix metalloproteinase-2: solution structure, dynamics, and function of the COL-23 two-domain construct.
Human matrix metalloproteinase-2 (MMP-2) contains an array of three fibronectin type II (FII) modules postulated to interact with gelatin (denatured collagen). Here, we verify that the NMR solution structure of the third FII repeat (COL-3) is similar to that of the second FII repeat (COL-2); characterize its ligand-binding properties; and derive dynamics properties and relative orientation in s...
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Plasma fibronectin, which is also known as cold-insoluble globulin, consists of two polypeptide chains of approximately 250,000 daltons joined by disulfide bonds located near one end of the molecule. Proteolytic digestion of human plasma fibronectin and NHz-terminal sequence analysis of some of the fragments produced were used to locate the gelatin-binding region of fibronectin within the intac...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.m101105200